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Antineoplastic and immunomodulating drugs, Six-membered rings

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Cyclic compounds (35)
Antineoplastic drugs (32)
Pharmaceuticals (19)
Aromatase inhibitors (10)
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Hormonal antineoplastic drugs (10)
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Antineoplastic and immunomodulating drug (9)
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11-cis Retinoic Acid (302-79-4, 4759-48-2)  
Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo.
9,13-Di-cis-retinoic acid (302-79-4, 5352-74-9, 4759-48-2)  
9,13-retinoic acid  ·  9-cis,13-cis-retinoic acid  ·  9,13-di-cis-RA
Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis.
Isotretinoin (4759-48-2, 97950-17-9)  
Accutane  ·  13 cis Retinoic Acid  ·  13-cis-Retinoic Acid
Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis.
Trimethoprim (738-70-5)  
Proloprim  ·  Trimpex
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
Nilotinib (641571-10-0)  
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
Bortezomib (179324-69-7)  
Bortezomib (BAN, INN and USAN; marketed as Velcade by Millennium Pharmaceuticals; Neomib by Getwell and Bortecad by Cadila Healthcare) is an anti-cancer drug and the first therapeutic proteasome inhibitor to be used in humans. Proteasomes are cellular complexes that break down proteins. In some cancers, the proteins that normally kill cancer cells are broken down too quickly.
Retinoic acid (302-79-4, 4759-48-2, 97950-17-9)  
Tretinoin  ·  Vitamin A Acid  ·  trans Retinoic Acid
Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis.
Sorafenib (284461-73-0)  
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
altretamine (645-05-6)  
Hemel  ·  Hexamethylmelamine  ·  Hexalen
Altretamine (trade name Hexalen) is an antineoplastic agent. It was approved by the U.S. FDA in 1990.
Alitretinoin (5300-03-8)  
Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid.
5-azacytidine (320-67-2)  
Azacytidine  ·  Azacitidine  ·  Vidaza
Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2′-deoxycytidine), are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.
pipobroman (54-91-1)  
Vercyte  ·  Abbott Brand of Pipobroman
Pipobroman (trade names Vercite, Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. It is marketed by Abbott Laboratories.
Gefitinib (184475-35-2)  
Gefitinib (ZD1839) (INN, , trade name Iressa) is a drug used for certain breast, lung and other cancers. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
mycophenolic acid (483-60-3, 24280-93-1)  
mycophenolate mofetil  ·  Cellcept  ·  myfortic
Mycophenolic acid, less accurately called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation. It inhibits an enzyme needed for the growth of T cells and B cells. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability.
Decitabine (2353-33-5)  
Dacogen  ·  5-deoxyazacytidine  ·  2'-deoxy-5-azacytidine
Decitabine (trade name Dacogen), or 5-aza-2'-deoxycytidine, acts as an Nucleic Acid Synthesis Inhibitor. It is a drug for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML). Chemically, it is a cytidine analog.
Triethylenemelamine (51-18-3)  
Triethylene Melamine  ·  Tretamine  ·  2,4,6-Triethylimino-1,3,5-Triazine
Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy. It can cause chromatid aberrations in cell models.
FENARIMOL (60168-88-9)  
alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol  ·  Rubigan-4  ·  Rubigan 12 RC
Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew.
Darusentan (171714-84-4)  
Darusentan (LU-135252; HMR-4005) is an endothelin receptor antagonist. Gilead Colorado, a subsidiary of Gilead Sciences, under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension. In June 2003, Myogen licensed the compound from Abbott for its application in the cancer field.
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