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Antineoplastic drugs, Blister agents

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Antineoplastic and immunomodulating drugs (26)
Alkylating antineoplastic agents (20)
DNA replication inhibitors (20)
Nitrogen mustards (20)
Halides (18)
Organochlorides (16)
Organohalides (16)
Antineoplastic and immunomodulating drug (8)
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Phosphorodiamidates (5)
Sex hormones (5)
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Amines (3)
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Estrogen esters (3)
Estrogens (3)
Hormonal agents (3)
Oxazaphosphinans (3)
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Acid anhydrides (2)
Androgen esters (2)
Androgens and anabolic steroids (2)
Carboxylic anhydrides (2)
Chalcogenides (2)
Chlorides (2)
Estradiol esters (2)
Ethers (2)
Experimental cancer drugs (2)
Nandrolone esters (2)
Organoarsenic chlorides (2)
Progestogen esters (2)
Progestogens (2)
Sulfides (2)
Synthetic estrogens (2)
Terpenes and terpenoids (2)
Testosterone (2)
Thioethers (2)
Acids (1)
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Hormonal antineoplastic drugs (1)
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Mustard gas (505-60-2)  
Sulfur mustard, commonly known as mustard gas, is the prototypical substance of the sulfur-based family of cytotoxic and vesicant chemical warfare agents known as the sulfur mustards which have the ability to form large blisters on exposed skin and in the lungs. They have a long history of use as a blister-agent in warfare and along with organoarsenic compounds are the most well-studied such agents. Related chemical compounds with similar chemical structure and similar properties form a class of compounds known collectively as sulfur mustards or mustard agents.
melphalan (1465-26-5, 148-82-3)  
Alkeran  ·  Phenylalanine Mustard  ·  Sarcolysine
Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
chlorambucil (305-03-3)  
Leukeran  ·  CB 1348  ·  Lympholysin
Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth.
Merphalan (531-76-0)  
Melphalan  ·  Alkeran  ·  Phenylalanine Mustard
mechlorethamine (51-75-2, 538-07-8)  
Nitrogen Mustard  ·  Mustargen  ·  Mechlorethamine Hydrochloride
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) Embichin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication.
Bendamustine (16506-27-7)  
Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. It is given by injection into a vein. Common side effects include low blood cell counts, fever, nausea, diarrhea, loss of appetite, cough, and rash.
Bis(2-chloroethyl)ethylamine (538-07-8)  
Bis(2-chloroethyl)ethylamine is the organic compound with the formula C2H5N(CH2CH2Cl)2. Often abbreviated HN1, it is a powerful vesicant and a nitrogen mustard gas used for chemical warfare. HN1 was developed in the 1920s and 1930s to remove warts and later as a military agent.
trichlormethine (555-77-1)  
Tris(2-chloroethyl)amine is the organic compound with the formula N(CH2CH2Cl)3. Often abbreviated HN3, it is a powerful blister agent and a nitrogen mustard gas (although it is not a gas) used for chemical warfare. HN3 was the last of the nitrogen mustard agents developed.
Dichlorophenylarsine (696-28-6)  
phenyldichloroarsine
Phenyldichloroarsine, NATO abbreviation PD, is an organic arsenical vesicant and vomiting agent developed by Germany and France for use as a chemical warfare agent during World War I. The agent is known by multiple synonyms and is technically classified as a vesicant, or blister agent.
Chlornaphazine (494-03-1)  
chlornaphazin
Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease. However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued. The International Agency for Research on Cancer has listed chlornaphazine as a human carcinogen.
cantharidin (57775-27-6, 56-25-7)  
Cantharides  ·  Cantharidine
Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. It is a burn agent or a poison in large doses, but preparations containing it were historically used as aphrodisiacs. In its natural form, cantharidin is secreted by the male blister beetle and given to the female as a copulatory gift during mating.
Estradiol mustard (22966-79-6)  
Estradiol mustard (developmental code name NSC-112259), also known as chlorphenacyl estradiol diester, as well as estradiol 3,17β-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and alkylating antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard alkylating antineoplastic agents.
Glufosfamide (132682-98-5)  
Glufosfamide, also known as glucophosphamide, D-glucose isophosphoramide mustard, D-19575 is an experimental cytotoxic chemotherapeutic agent for treatment of malignancies.
METHYLDICHLOROARSINE (593-89-5)  
Methyldichloroarsine, sometimes abbreviated "MD", is an organoarsenic compound with the formula CH3AsCl2. This colourless volatile liquid is a highly toxic vesicant that has been used in chemical warfare.
Trofosfamide (72282-85-0, 72282-84-9, 22089-22-1)  
Z 4828  ·  Ixoten  ·  Genoxal Trofosfamida
Trofosfamide (INN) is a nitrogen mustard alkylating agent. It is sometimes abbreviated "TRO".
Carboxyphosphamide (22788-18-7)  
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).
4-Hydroperoxycyclophosphamide (39800-16-3)  
Perfosfamide, or 4-hydroperoxycyclophosphamide (trade name Pergamid) was an experimental drug candidate for blood cancers that was rejected by the FDA in 1993 and never reached the market.
Mafosfamide (88859-04-5)  
Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein. Several Phase I trials have been completed.
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