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Cardiovascular system drug, Spiro compounds


Antiandrogens (5)
Antihypertensive agents (5)
Antimineralocorticoids (5)
Diuretics (5)
Drugs acting on the cardiovascular system (5)
Drugs acting on the genito-urinary system (5)
Hormonal agents (5)
Potassium-sparing diuretics (5)
Sex hormones (5)
Systemic hormonal preparations (5)
Cyclic compounds (3)
Cycloalkanes (3)
Cyclopropanes (3)
Progestogens (3)
Three-membered rings (3)

Prorenone (49848-04-6)  
Prorenone (developmental code name SC-23133) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed. It is the lactonic form of prorenoic acid (prorenoate), and prorenoate potassium (SC-23992), the potassium salt of prorenoic acid, also exists. Prorenoate potassium is about 8 times more potent than spironolactone as an antimineralocorticoid in animals, and it may act as a prodrug to prorenone.
Spirorenone (74220-07-8)  
6 beta, 7 beta, 15 beta, 16 beta-dimethylene-1,4-androstadiene-(17(beta-1')-spiro-5')-perhydrofuran-2',3-dione
Spirorenone (INN) (developmental code name ZK-35973) is a steroidal antimineralocorticoid of the spirolactone group that was never marketed. Spirorenone possesses 5–8 times the antimineralocorticoid activity of spironolactone in animal studies. The initial discovery of spirorenone was deemed a great success, as no compound with greater antimineralocorticoid activity had been developed since spironolactone in 1957.
20-Spirox-4-ene-3,20-dione (976-70-5)  
SC-5233, also known as 6,7-dihydrocanrenone or 20-spirox-4-ene-3,20-dione, is a steroidal antimineralocorticoid of the spirolactone group which was developed by G. D. Searle & Company in the 1950s but was never marketed.
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Cardiovascular system drug
Spiro compounds