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Nervous system drug, Stimulants

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Drugs acting on the nervous system (34)
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phenylpropanolamine (36393-56-3, 48115-38-4, 14838-15-4, 37577-28-9)  
Phenylpropanolamine Hydrochloride  ·  Norephedrine  ·  Dexatrim
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
(-)-Norephedrine (492-41-1, 14838-15-4, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Norephedrine
(-)-NORPSEUDOEPHEDRINE (36393-56-3, 53643-20-2, 37577-07-4)  
L-Norpseudoephedrine, or (−)-norpseudoephedrine, is a psychostimulant drug of the amphetamine family. It is one of the four optical isomers of phenylpropanolamine, the other three being cathine ((+)-norpseudoephedrine), (−)-norephedrine, and (+)-norephedrine; as well as one of the two enantiomers of norpseudoephedrine (the other, of course, being cathine). Similarly to cathine, L-norpseudoephedrine acts as a releasing agent of norepinephrine (EC50 = 30 nM) and to a lesser extent of dopamine (EC50 = 294 nM).
Norephedrine (36393-56-3, 14838-15-4, 37577-28-9, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Dexatrim
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
1,3-Dimethylpentylamine (105-41-9)  
methylhexaneamine  ·  4-methyl-2-hexylamine
Methylhexanamine (trade names Forthane, Geranamine) or methylhexamine, commonly known as 1,3-dimethylamylamine (1,3-DMAA) or simply dimethylamylamine (DMAA), is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1944 until it was voluntarily withdrawn from the market in 1983. Since 2006 methylhexanamine has been sold extensively under many names as a stimulant or energy-boosting dietary supplement under the claim that it is similar to certain compounds found in geraniums, but its safety has been questioned as a number of adverse events and at least five deaths have been associated with methylhexanamine-containing supplements. It is banned by many sports authorities and governmental agencies.
diphenylpyraline (147-20-6)  
diphenylpyraline hydrochloride  ·  diphenylpyraline maleate (2:1)  ·  Lergobine
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.
Cathine (36393-56-3, 492-39-7, 37577-28-9)  
norpseudoephedrine  ·  norpseudoephedrine, (R*,S*)-isomer  ·  norpseudoephedrine, conjugate monoacid, (R-(R*,S*))-isomer
Cathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which acts as a stimulant. Along with cathinone, it is found naturally in Catha edulis (khat), and contributes to its overall effects. It has approximately 10-14% the potency of amphetamine.
Aceglutamid (2490-97-3)  
Aceglutamide (brand name Neuramina), or aceglutamide aluminum (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability.
2-Aminoindan (2975-41-9)  
2-aminoindan hydrochloride  ·  2-aminoindane
2-Aminoindane (2-AI) is a psychoactive drug and research chemical with stimulant properties. It is a rigid pre-analogue of amphetamine and partially substitutes for it in rat discrimination tests.
Abt-418 (147402-53-7)  
ABT-418 is a drug developed by Abbott, that has nootropic, neuroprotective and anxiolytic effects, and has been researched for treatment of both Alzheimer's disease and ADHD. It acts as an agonist at neural nicotinic acetylcholine receptors, subtype-selective binding with high affinity to the α4β2, α7/5-HT3, and α2β2 nicotinic acetylcholine receptors but not the α3β4 subtype familiar to nicotine. ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if another similar drug will be used instead.
Fenozolone (15302-16-6)  
Fenozolone (Ordinator) was developed by Laboratoires Dausse in the 1960s and is a psychoactive drug and stimulant related to pemoline and 4-methylaminorex which acts as a norepinephrine-dopamine releasing agent (NDRA).
4-Benzylpiperidine (31252-42-3)  
4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It has a fast onset of action and a short duration.
N-Acetyl-L-glutamine (2490-97-3, 35305-74-9)  
aceglutamide, aluminum (3:1) salt  ·  N-acetylglutamine  ·  aceglutamide
(1R)-2-amino-1-phenylpropan-1-ol (37577-28-9)  
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
Exp 561 (10206-89-0)  
EXP-561 is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine. It was developed in the 1960s by Du Pont and was suggested as a potential antidepressant but failed in trials and was never marketed.
Formetorex (15302-18-8)  
Formetorex (INN), also known as formetamide or N-formylamphetamine, is an amphetamine described as an anorectic which does not appear to have ever been marketed. Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines.
Difluoropine (156774-35-5)  
Difluoropine (O-620) is a stimulant drug synthesised from tropinone, which acts as a potent and selective dopamine reuptake inhibitor. Difluoropine is unique among the tropane-derived dopamine reuptake inhibitors in that the active stereoisomer is the (S) enantiomer rather than the (R) enantiomer, the opposite way round compared to natural cocaine. It is structurally related to benztropine and has similar anticholinergic and antihistamine effects in addition to its dopamine reuptake inhibitory action.
Chlormethamphetamine (1199-85-5)  
chloromethamphetamine  ·  Ro 4-6861  ·  4-chloromethamphetamine
para-Chloromethamphetamine (also known as 4-Chloromethamphetamine and 4-CMA) is a stimulant that is the N-methyl derivative and prodrug of the neurotoxic drug para-Chloroamphetamine. It has been found to decrease serotonin in rats. Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of 5-HT and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug.
5,5-Dimethyl-2-phenylmorpholine (42013-48-9)  
G-130 (GP-130, 2-Phenyl-5,5-dimethyltetrahydro-1,4-oxazine) is a drug with stimulant and anorectic effects, related to phenmetrazine.
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Nervous system drug
Stimulants
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