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Nervous system drug, www.sigmaaldrich.com

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Drugs acting on the nervous system (46)
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methadone (76-99-3)  
Dolophine  ·  Methadone Hydrochloride  ·  Amidone
Methadone, sold under the brand name Dolophine, among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence. Detoxification using methadone can either be done relatively rapidly in less than a month or gradually over as long as six months. While a single dose has a rapid effect, maximum effect can take five days of use.
Lysergide (50-37-3)  
LSD  ·  Lysergic Acid Diethylamide  ·  LSD 25
Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not. It is used mainly as a recreational drug and for spiritual reasons. LSD is typically either swallowed or held under the tongue.
(-)-Norephedrine (492-41-1, 14838-15-4, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Norephedrine
Norephedrine (36393-56-3, 14838-15-4, 37577-28-9, 700-65-2)  
Phenylpropanolamine  ·  Phenylpropanolamine Hydrochloride  ·  Dexatrim
Phenylpropanolamine (PPA) is a sympathomimetic agent which is used as a decongestant and appetite suppressant. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.
Fenclonine (1991-78-2, 7424-00-2)  
Fenclonine (L)-Isomer  ·  Fenclonine Hydrobromide  ·  Fenclonine, (D)-Isomer
Fenclonine, also known as para-chlorophenylalanine (PCPA), acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. It has been used experimentally to treat carcinoid syndrome, but the side effects, mostly hypersensitivity reactions and psychiatric disturbances, have prevented development for this use. The effects of serotonin depletion from fenclonine are so drastic that serotonin cannot even be detected immunohistochemically within the first day after administration of a control dose.
1,3-Dimethylpentylamine (105-41-9)  
methylhexaneamine  ·  4-methyl-2-hexylamine
Methylhexanamine (trade names Forthane, Geranamine) or methylhexamine, commonly known as 1,3-dimethylamylamine (1,3-DMAA) or simply dimethylamylamine (DMAA), is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1944 until it was voluntarily withdrawn from the market in 1983. Since 2006 methylhexanamine has been sold extensively under many names as a stimulant or energy-boosting dietary supplement under the claim that it is similar to certain compounds found in geraniums, but its safety has been questioned as a number of adverse events and at least five deaths have been associated with methylhexanamine-containing supplements. It is banned by many sports authorities and governmental agencies.
ANISOTROPINE METHYLBROMIDE (80-50-2, 70642-90-9)  
Valpin  ·  anisotropine methylbromide, (endo)-isomer  ·  octatropine
Octatropine methylbromide (INN) or anisotropine methylbromide (USAN), trade names Valpin, Endovalpin, Lytispasm and others, is a muscarinic antagonist and antispasmodic. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of peptic ulcer, and promoted as being more specific to the gastrointestinal tract than other anticholinergics, although its selectivity was questioned in later studies.
Butyl 4-aminobenzoate (94-25-7)  
Butesin  ·  butamben  ·  butyl aminobenzoate
Butamben is a local anesthetic. It is the ester of 4-aminobenzoic acid and butanol. A white, odourless, crystalline powder.
Cisatracurium besylate (96946-42-8)  
Cisatracurium (formerly recognized as 51W89, and marketed as Nimbex) is a bisbenzyltetrahydroisoquinolinium that has effect as a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It shows intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium.
Atracurium besylate (96946-42-8, 64228-79-1, 64228-81-5)  
Atracurium  ·  Tracrium  ·  BW 33A
Atracurium besilate is a medication used in addition to other medications to provide skeletal muscle relaxation during surgery or mechanical ventilation. It can also be used to help with endotracheal intubation but suxamethonium (succinylcholine) is generally preferred if this needs to be done quickly. It is given by injection into a vein.
Fluspirilene (1841-19-6)  
Imap  ·  Fluspirilen beta  ·  Hexal Brand of Fluspirilene
Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.
1-Aminocyclopropanecarboxylic acid (22059-21-8)  
1-aminocyclopropane-1-carboxylic acid  ·  1-aminocyclopropane-1-carboxylic acid, 14C-labeled  ·  ACC acid
1-Aminocyclopropane-1-carboxylic acid (ACC) is a disubstituted cyclic α-amino acid in which a three-membered cyclopropane ring is fused to the Cα atom of the amino acid. ACC plays an important role in the biosynthesis of the plant hormone ethylene. It is synthesized by the enzyme ACC synthase ( EC 4.4.1.14) from methionine and converted to ethylene by ACC oxidase (EC 1.14.17.4).
Etiracetam (33996-58-6)  
Etiracetam is a chemical compound belonging to the racetam family, which was developed as a nootropic drug. It is racemic; its biologically active enantiomeric form is levetiracetam, now marketed as an antiepileptic drug.
1,3-Di-o-tolylguanidine (97-39-2)  
1,3-ditolylguanidine hydrochloride  ·  1,3-di-ortho-tolyl-guanidine  ·  N,N'-bis(2-methylphenyl)guanidine
Ditolylguanidine is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.
bromperidol (10457-90-6)  
R 11,333  ·  bromperidol, 82Br-labeled  ·  Tesoprel
Bromperidol (marketed as Bromidol, Bromodol) is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.
alpha-Chloralose (15879-93-3)  
Chloralose  ·  alpha Chloralose  ·  Glucochloral
Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative. Chemically, it is a chlorinated acetal derivative of glucose.
Cyamemazine (3546-03-0)  
cyamamazine  ·  10-(3-dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrile  ·  cyamepromazine
Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was introduced by Theraplix in France in 1972 and later in Portugal as well. It is used for the treatment of schizophrenia and, especially, for psychosis-associated anxiety, due to its unique anxiolytic efficacy. Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism, it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7.
Marindinin (587-63-3)  
Dihydrokavain is one of the six major kavalactones found in the kava plant. It appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.
N-Acetyl-DL-leucine (99-15-0, 1188-21-2)  
N-acetyl-L-leucine  ·  acetylleucine  ·  acetyl-DL-leucine
Acetylleucine is a drug used in the treatment of vertigo and cerebellar ataxia.
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