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Organochlorides, Pharmaceuticals


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lindane (6108-12-9, 6108-11-8, 608-73-1, 319-85-7, 6108-10-7, 319-86-8, 6108-13-0, 58-89-9, 319-84-6)  
Hexachlorocyclohexane (HCH) is any of several polyhalogenated organic compounds consisting of a six-carbon ring with one chlorine and one hydrogen attached to each carbon. There are many isomers for this structure, differing by the stereochemistry of the individual chlorine substituents on the cyclohexane. It is sometimes erroneously called "benzene hexachloride" (BHC).
Trichloroethene  ·  Trilene  ·  Ethinyl Trichloride
The chemical compound trichloroethylene is a halocarbon commonly used as an industrial solvent. It is a clear non-flammable liquid with a sweet smell. It should not be confused with the similar 1,1,1-trichloroethane, which is commonly known as chlorothene.
Bichloroacetic Acid  ·  Sodium Dichloroacetate  ·  Potassium Dichloroacetate
Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the chemical compound with formula CHCl 2COOH. It is an acid, an analogue of acetic acid, in which 2 of the 3 hydrogen atoms of the methyl group have been replaced by chlorine atoms. Like the other chloroacetic acids, it has various practical applications.
halothane (151-67-7)  
Fluothane  ·  Ftorotan  ·  Narcotan
Halothane, sold under the brandname Fluothane among others, is a general anesthetic. It can be used to start or maintain anaesthesia. One of its benefits is that it does not increase the production of saliva which can be particularly useful in those who are difficult to intubate.
chloral hydrate (302-17-0)  
Chloral hydrate is a geminal diol with the formula C2H3Cl3O2. It is a colorless solid. It has limited use as a sedative and hypnotic pharmaceutical drug.
isoflurane (26675-46-7)  
Isoflurane, sold under the trade name Forane among others, is a general anesthetic. It can be used to start or maintain anesthesia. Often another medication, however, is used to start anesthesia due to airway irritation with isoflurane.
melphalan (1465-26-5, 148-82-3)  
Alkeran  ·  Phenylalanine Mustard  ·  Sarcolysine
Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring.
lomustine (13010-47-4)  
CCNU  ·  CeeNU  ·  NSC-79037
Lomustine (INN), abbreviated CCNU (original brand name (formerly available) is CeeNU, now marketed as Gleostine), is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood-brain barrier.
Enflurane (13838-16-9)  
Ethrane  ·  Enfran  ·  Alyrane
Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use.
ketamine (6740-88-1)  
Ketamine Hydrochloride  ·  Ketalar  ·  Ketaset
Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include for chronic pain and for sedation in intensive care.
chlorambucil (305-03-3)  
Leukeran  ·  CB 1348  ·  Lympholysin
Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth.
mechlorethamine (51-75-2, 538-07-8)  
Nitrogen Mustard  ·  Mustargen  ·  Mechlorethamine Hydrochloride
Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) Embichin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen. It is the prototype of alkylating agents, a group of anticancer chemotherapeutic drugs. It works by binding to DNA, crosslinking two strands and preventing cell duplication.
chloramphenicol (56-75-7, 2787-09-9)  
Chloromycetin  ·  Ophthochlor  ·  Cloranfenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever.
Methoxyflurane (76-38-0)  
Penthrane  ·  Anecotan  ·  Pentrane
Methoxyflurane (INN), formerly marketed as Penthrane by Abbott Laboratories, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction by Joseph F. Artusio et al in 1960 until the late 1970s. It was first synthesized in the late 1940s by William T.
Bendamustine (16506-27-7)  
Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. It is given by injection into a vein. Common side effects include low blood cell counts, fever, nausea, diarrhea, loss of appetite, cough, and rash.
CHLORAL (75-87-6)  
Chloral, also known as trichloroacetaldehyde or trichloroethanal, is the organic compound with the formula Cl3CCHO. This aldehyde is a colourless oily liquid that is soluble in a wide range of solvents. It reacts with water to form chloral hydrate, a once widely used sedative and hypnotic substance.
phenoxybenzamine (59-96-1)  
Dibenzyline  ·  Phenoxybenzamine Hydrochloride  ·  Dibenyline
Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-selective, irreversible alpha blocker.
Fotemustine (92118-27-9)  
Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067).
Clofarabine (123318-82-1)  
Clofarabine is a purine nucleoside antimetabolite marketed in the US and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. It is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed.
Clobetasol  ·  Temovate  ·  Dermovate
Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available.
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