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Pyrimidines, Psychopharmacology, Ureas

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Antidepressants (1)
Antipsychotics (1)
Anxiolytics (1)
Azapirones (1)
Cyclic compounds (1)
Drugs acting on the nervous system (1)
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Eptapirone (179756-85-5)  
Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family. Its affinity for the 5-HT1A receptor was reported to be 4.8 nM (Ki) (or 8.33 (pKi)), and its intrinsic activity approximately equal to that of serotonin (i.e., 100%). Eptapirone and related high-efficacy 5-HT1A full and super agonists such as befiradol and F-15,599 were developed under the hypothesis that the maximum exploitable therapeutic benefits of 5-HT1A receptor agonists might not be able to be seen without the drugs employed possessing sufficiently high intrinsic activity at the receptor.
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Pyrimidines
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