Cyclic compounds (15)
Six-membered rings (15)
Aromatic amines (3)
Alpha blockers (1)
Alpha-2 blockers (1)
Chelating agents (1)
Sigma Aldrich (11)
AK Scientific (9)
TCI Chemicals (8)
Oakwood Chemical (6)
Sulfadimidine · Sulphamezathine · Sulfadimezine
Sulfadimidine or sulfamethazine is a sulfonamide antibacterial. There are non-standardizeda abbreviations for it as "sulfadimidine" (abbreviated SDI and more commonly but less reliablyb SDD) and as "sulfamethazine" (abbreviated SMT and more commonly but less reliablyc SMZ). Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.
Proloprim · Trimpex
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
Tebupirimfos, also known as phostebupirim, is an organothiophosphate insecticide. It is used on corn crops, including popcorn. The Pesticide Action Network has classified tebupirimphos as a "bad actor" due to its specific hazards.
Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine.
Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure.
sulfadimethoxine (122-11-2, 1037-50-9)
Deposul · Sulphadimethoxine
Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections and can be given as a standalone or combined with ormetoprim to broaden the target range. Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA.
Elkosin · Sulfaisodimidine · Aristamid Augentropfen
Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003), sulfamethin and sulfaisodimidine, is a sulfonamide antibacterial. It is closely related to sulfadimidine.
2-(1-Piperazinyl)pyrimidine (125523-53-7, 20980-22-7)
MJ-13653 · 1-(2-pyrimidinyl)piperazine · MJ 13653
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3–40 nM) and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414 nM; Emax = 54%). It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.
Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen and as of 2016 Melior was repurposing it for diabetes.
sulfene · sulfaperine · isosulfamerazine
Sulfaperin (or sulfaperine) is a sulfonamide antibacterial.
2,4-Diaminopyrimidine is a diaminopyrimidine.
2-isobutyrylthiamine disulfide · Surmenalit · bis(2-(isobutyryloxy)ethyl-1-N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido-2-propene-1-yl)disulfide
Sulbutiamine (brand name: Arcalion) is a synthetic derivative of thiamine (vitamin B1). As a dimer of two modified thiamine molecules, it is a lipophilic compound that crosses the blood–brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Sulbutiamine was discovered in Japan in an effort to develop more useful thiamine derivatives since it was hoped that increasing the lipophilicity of thiamine would result in better pharmacokinetic properties.
RS-127445 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors. The role of the 5-HT2B receptor in the body is still poorly understood, and RS-127445 has been a useful tool in unravelling the function of the various systems in which this receptor is expressed.