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Pyrimidines, www.sigmaaldrich.com

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diazinon (333-41-5)  
Bazudine  ·  Neotsidol  ·  Neocidol
Diazinon (IUPAC name: O,O-Diethyl O-[4-methyl-6-(propan-2-yl)pyrimidin-2-yl] phosphorothioate, INN - Dimpylate), a colorless to dark brown liquid, is a thiophosphoric acid ester developed in 1952 by Ciba-Geigy, a Swiss chemical company (later Novartis and then Syngenta). It is a nonsystemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon was heavily used during the 1970s and early 1980s for general-purpose gardening use and indoor pest control.
propylthiouracil (51-52-5)  
6 Propyl 2 Thiouracil  ·  6-Propyl-2-Thiouracil
Propylthiouracil (PTU) is a medication used to treat hyperthyroidism. This includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. In a thyrotoxic crisis it is generally more effective than methimazole.
sulfamethazine (57-68-1)  
Sulfadimidine  ·  Sulphamezathine  ·  Sulfadimezine
Sulfadimidine or sulfamethazine is a sulfonamide antibacterial. There are non-standardizeda abbreviations for it as "sulfadimidine" (abbreviated SDI and more commonly but less reliablyb SDD) and as "sulfamethazine" (abbreviated SMT and more commonly but less reliablyc SMZ). Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.
Trimethoprim (738-70-5)  
Proloprim  ·  Trimpex
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
Pirimiphos-methyl (29232-93-7)  
pirimiphos methyl  ·  PP 511  ·  pirimiphosmethyl
Pirimiphos-methyl, marketed as Actellic, and Sybol is a phosphorothioate used as an insecticide. It was originally developed by Imperial Chemical Industries Ltd., now Syngenta, in 1967. This is one of several compounds used for vector control of Triatoma.
Nilotinib (641571-10-0)  
Nilotinib (AMN107, trade name Tasigna), in the form of the hydrochloride monohydrate salt, is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia. Structurally related to imatinib, it was developed based on the structure of the Abl-imatinib complex to address imatinib intolerance and resistance. Nilotinib is a selective Bcr-Abl kinase inhibitor that is 10–30 fold more potent than imatinib in inhibiting Bcr-Abl tyrosine kinase activity and proliferation of Bcr-Abl expressing cells.
Tebupirimfos (96182-53-5)  
Tebupirimfos, also known as phostebupirim, is an organothiophosphate insecticide. It is used on corn crops, including popcorn. The Pesticide Action Network has classified tebupirimphos as a "bad actor" due to its specific hazards.
Pirinixic acid (50892-23-4)  
Pirinixic acid is a peroxisome proliferator-activated receptor alpha (PPARα) agonist that is under experimental investigation for prevention of severe cardiac dysfunction, cardiomyopathy and heart failure as a result of lipid accumulation within cardiac myocytes. Treatment is primarily aimed at individuals with an adipose triglyceride lipase (ATGL) enzyme deficiency or mutation because of the essential PPAR protein interactions with free fatty acid monomers derived from the ATGL catalyzed lipid oxidation reaction. It was discovered as WY-14,643 in 1974.
Voriconazole (137234-62-9)  
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. It can be taken by mouth or used by injection into a vein.
2-thiouracil (141-90-2)  
Thiouracil
Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure.
sulfamerazine (127-79-7)  
Methylsulfadiazine  ·  Mebacid  ·  Trimetox
Sulfamerazine is a sulfonamide antibacterial.
SULFADOXINE (2447-57-6)  
Sulforthomidine  ·  Ro 4 4393  ·  Sulformethoxine
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria. It was previously used to prevent malaria but due to high levels of resistance, this use is no longer recommended routinely. It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.
FENARIMOL (60168-88-9)  
alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol  ·  Rubigan-4  ·  Rubigan 12 RC
Fenarimol, sold under the tradenames Bloc, Rimidin and Rubigan, is a fungicide which acts against rusts, blackspot and mildew fungi. It is used on ornamental plants, trees, lawns, tomatoes, peppers, eggplants, cucumbers and melons. It is mainly used to control powdery mildew.
sulfadimethoxine (122-11-2, 1037-50-9)  
Deposul  ·  Sulphadimethoxine
Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections and can be given as a standalone or combined with ormetoprim to broaden the target range. Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA.
PYRIMIDINE (289-95-2, 25247-63-6)  
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. The other diazines are pyrazine (nitrogen atoms at the 1 and 4 positions) and pyridazine (nitrogen atoms at the 1 and 2 positions).
sulfameter (651-06-9)  
Sulfamethoxydine  ·  Sulfametoxydiazine  ·  Sulfametin
Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
Bupirimate (41483-43-6)  
Nimrod  ·  2-aminoethyl-5-butyl-4(N)-methylsulfonate-6-methylpyrimidine
Bupirimate (systematic name 5-butyl-2-ethylamino-6-methylpyrimidin-4-yldimethylsulphamate; brand names Nimrod and Roseclear 2) is an active ingredient of plant protection products (or pesticides), which has an effect as a fungicide. It belongs to the chemical family of pyrimidines. Bupirimate has translaminar mobility and systemic translocation in the xylem.
SULFISOMIDINE (515-64-0)  
Elkosin  ·  Sulfaisodimidine  ·  Aristamid Augentropfen
Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003), sulfamethin and sulfaisodimidine, is a sulfonamide antibacterial. It is closely related to sulfadimidine.
piribedil (3605-01-4)  
ET 495  ·  Trivastal  ·  Piribedil Mesylate
Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
2-(1-Piperazinyl)pyrimidine (125523-53-7, 20980-22-7)  
MJ-13653  ·  1-(2-pyrimidinyl)piperazine  ·  MJ 13653
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3–40 nM) and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414 nM; Emax = 54%). It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.
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