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Pyrimidines

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GLYMIDINE (339-44-6, 3459-20-9)  
glidiazine  ·  glycodiazine
Glymidine sodium (INN, also known as glycodiazine; trade name Gondafon) is a sulfonamide antidiabetic drug, structurally related to the sulfonylureas. It was first reported in 1964, and introduced to clinical use in Europe in the mid to late 1960s.
sulfadimethoxine (122-11-2, 1037-50-9)  
Deposul  ·  Sulphadimethoxine
Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections and can be given as a standalone or combined with ormetoprim to broaden the target range. Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA.
PYRIMIDINE (289-95-2, 25247-63-6)  
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. The other diazines are pyrazine (nitrogen atoms at the 1 and 4 positions) and pyridazine (nitrogen atoms at the 1 and 2 positions).
MOXONIDINE (75438-57-2)  
Moxon  ·  Zint  ·  Cynt
Moxonidine (INN) is a new-generation centrally acting antihypertensive drug licensed for the treatment of mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure. In addition, it demonstrates favourable effects on parameters of the insulin resistance syndrome, apparently independent of blood pressure reduction.
Darusentan (171714-84-4)  
Darusentan (LU-135252; HMR-4005) is an endothelin receptor antagonist. Gilead Colorado, a subsidiary of Gilead Sciences, under license from Abbott Laboratories, is developing darusentan for the potential treatment of uncontrolled hypertension. In June 2003, Myogen licensed the compound from Abbott for its application in the cancer field.
sulfameter (651-06-9)  
Sulfamethoxydine  ·  Sulfametoxydiazine  ·  Sulfametin
Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
thonzylamine (91-85-0)  
Anahist  ·  Neohetramine  ·  thonzylamine hydrochloride
Thonzylamine (or neohetramine) is an antihistamine and anticholinergic used as an antipruritic.
Lesopitron (132449-46-8)  
Lesopitron (E-4424) is a selective full agonist of the 5-HT1A receptor which is structurally related to the azapirones. In 2001 it was under development by Esteve as an anxiolytic for the treatment of generalized anxiety disorder (GAD). It made it to phase II clinical trials but was apparently discontinued as no new information on lesopitron has surfaced since.
urapidil (34661-75-1)  
urapidil, 2,3-(14)C2-labeled  ·  6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil  ·  urapidil monohydrochloride
Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist. Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum.
Bupirimate (41483-43-6)  
Nimrod  ·  2-aminoethyl-5-butyl-4(N)-methylsulfonate-6-methylpyrimidine
Bupirimate (systematic name 5-butyl-2-ethylamino-6-methylpyrimidin-4-yldimethylsulphamate; brand names Nimrod and Roseclear 2) is an active ingredient of plant protection products (or pesticides), which has an effect as a fungicide. It belongs to the chemical family of pyrimidines. Bupirimate has translaminar mobility and systemic translocation in the xylem.
SULFISOMIDINE (515-64-0)  
Elkosin  ·  Sulfaisodimidine  ·  Aristamid Augentropfen
Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003), sulfamethin and sulfaisodimidine, is a sulfonamide antibacterial. It is closely related to sulfadimidine.
piribedil (3605-01-4)  
ET 495  ·  Trivastal  ·  Piribedil Mesylate
Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties.
Iclaprim (192314-93-5)  
Iclaprim is an antibiotic drug candidate that is active against Gram positive organisms. It is administered intravenously. In vitro, iclaprim is active against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), strains of Streptococcus pneumoniae resistant to several common antibiotics, and some Gram-negative bacteria.
2-(1-Piperazinyl)pyrimidine (125523-53-7, 20980-22-7)  
MJ-13653  ·  1-(2-pyrimidinyl)piperazine  ·  MJ 13653
1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3–40 nM) and, to a much lesser extent, as a partial agonist of the 5-HT1A receptor (Ki = 414 nM; Emax = 54%). It has negligible affinity for the dopamine D2, D3, and D4 receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.
Tirilazad (110101-66-1)  
Tirilazad is a drug that has been proposed to treat acute ischaemic stroke. When tested on animal models, tirilazad protects brain tissue, and reduces brain damage. However, the drug fails to treat, and even worsens a stroke when studied on a human being.
Tandospirone (87760-53-0)  
Tandospirone (brand name Sediel) is an anxiolytic and antidepressant drug used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.
THONZONIUM BROMIDE (553-08-2)  
Thonzonium bromide is a monocationic detergent. A solution of it is thus a surfactant and a detergent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate of the containing solution. It is used in cortisporin-TC ear drops to help penetration of active ingredients through cellular debris for its antibacterial action.
NIMUSTINE (42471-28-3)  
ACNU  ·  NSC 245382
Nimustine (INN) is a nitrosourea alkylating agent.
benfotiamine (22457-89-2)  
Neurostop  ·  BTMP-benfo  ·  S-benzoylthiamine monophosphate
Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It is marketed as a dietary supplement in most of the developed world, and as a pharmaceutical drug in some countries for treating diabetic neuropathy under the trade name Milgamma and others. Combination drugs with pyridoxine or cyanocobalamin are also marketed in a few countries.
TOLIMIDONE (41964-07-2)  
Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen and as of 2016 Melior was repurposing it for diabetes.
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